Tottenham Hotspur duo Eric Dier and Harry Winks have both been ruled out of the game against Crystal Palace on Wednesday night.
The London Evening Standard reports that both players will miss the match, in what will be Tottenham’s first in their brand new stadium.
To miss such a historic occasion will come as a huge blow to both players, but the game has come around too quickly for the pair.
Dier has been struggling with an injury after coming off while on international duty with England last month.
Winks has been out of action since the club’s Champions League win over Bundesliga side Borussia Dortmund.
There had been some suggestions that Winks could be back sooner but he remains sidelined.
This has left Spurs facing a potential injury crisis in midfield, with only Moussa Sissoko among the fully fit first-team regulars.
Youngster Oliver Skipp or Victor Wanyama could come into the team on Wednesday night but neither have featured regularly for Spurs this season.
